Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516879 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL2609726 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL3519758 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL9010563 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL17354893 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL12464613 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL3519755 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP17A1CDC25ACDC25BNR1I2 | |
| SCHEMBL14495201 | 0.84 | NR1I2 (0.44) | CYP19A1CDC25ACDC25BNR1I2PGR | |
| SCHEMBL12464968 | 0.84 | CYP19A1 (0.49) | CYP19A1CDC25ACDC25BNR1I2PGR | |
| SCHEMBL13669231 | 0.84 | CYP19A1 (0.49) | CYP19A1CDC25ACDC25BNR1I2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222635-A2 | NEW VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009067578-A2 | NEW VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | ABBOTT LABORATORIES (US) | 2009-05-28 | — | — | WO | claimed |
| US-20090131379-A1 | VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | ABBOTT LABORATORIES (US) | 2009-05-21 | — | — | US | claimed |
| US-8377913-B2 | Vitamin D receptor activators and methods of making | ABBVIE INC. (US) | 2013-02-19 | — | — | US | disclosed |
| EP-2222635-A2 | NEW VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067578-A2 | NEW VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | ABBOTT LABORATORIES (US) | 2009-05-28 | — | — | WO | disclosed |
| US-20090131379-A1 | VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | ABBOTT LABORATORIES (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131379-A1 | VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | VDR, CYP2R1, CYP24A1 | CYP19A1 40/4885CYP17A1 123/4885CDC25A 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.