⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10944602 | 0.75 | CA12 (0.41) | — | |
| SCHEMBL2437768 | 0.74 | NPC1 (0.48) | — | |
| SCHEMBL9422620 | 0.74 | — | — | |
| SCHEMBL9422621 | 0.74 | — | — | |
| SCHEMBL6900485 | 0.72 | CYP1A2 (0.41) | — | |
| SCHEMBL126289 | 0.72 | ALOX15 (0.41) | — | |
| SCHEMBL125575 | 0.71 | ALOX15 (0.41) | — | |
| SCHEMBL1242106 | 0.71 | ACHE (0.42) | — | |
| SCHEMBL9422618 | 0.71 | INPPL1 (0.45) | — | |
| SCHEMBL11249468 | 0.69 | L3MBTL1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118773161-B | Mutant enzymes of serine kinase and sulfur lyase, fermentation production method thereof and application of mutant enzymes in production of mimosol | 华南师范大学 | 2025-02-14 | — | — | CN | disclosed |
| CN-118773161-A | Mutant enzymes of serine kinase and sulfur lyase, fermentation production method thereof and application of mutant enzymes in production of mimosol | 华南师范大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-110804045-B | Coumarin hybrid pyridone amide derivative with potential anti-AD activity and preparation method and application thereof | 浙江工业大学 | 2021-07-27 | — | — | CN | disclosed |
| CN-110804045-A | Coumarin hybrid pyridone amide derivative with potential anti-AD activity and preparation method and application thereof | 浙江工业大学 | 2020-02-18 | — | — | CN | disclosed |
| US-7786305-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. (US) | 2010-08-31 | — | — | US | disclosed |
| EP-1501507-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7230008-B2 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK & CO, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1501507-A4 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20060030582-A1 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | DEMARTINO JULIE | 2006-02-09 | — | — | US | disclosed |
| US-20050107422-A1 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK SHARP & DOHME LLC | 2005-05-19 | — | — | US | disclosed |
| US-20050101628-A1 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity | MERCK SHARP & DOHME LLC | 2005-05-12 | — | — | US | disclosed |
| EP-1501507-A2 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| US-6812234-B2 | CCR-2; INFLAMMATORY, IMMUNOREGULATORY, ALLERGIC, AND AUTOIMMUNE DISORDERS AND DISEASES | MERCK & CO., INC. | 2004-11-02 | — | — | US | disclosed |
| US-20040167156-A1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK SHARP & DOHME LLC | 2004-08-26 | — | — | US | disclosed |
| WO-2003092586-A2 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2003-11-13 | — | — | WO | disclosed |