Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAP2 | P11137 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30805773 | 1.00 | DYRK1A (0.54) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL30192723 | 0.88 | TERT (0.53) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL3290014 | 0.88 | DYRK1A (0.56) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL3123791 | 0.88 | TERT (0.53) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL30805770 | 0.88 | DYRK1A (0.56) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL3291598 | 0.86 | RXFP1 (0.46) | DYRK1ATERTTP53ALDH1A1 | |
| SCHEMBL9390934 | 0.85 | TERT (0.51) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL29196428 | 0.85 | TERT (0.54) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL13338301 | 0.85 | TERT (0.48) | DYRK1ATERTTP53NPC1POLB | |
| SCHEMBL3400668 | 0.83 | KDM4E (0.47) | DYRK1ATERTTP53CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511573-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1687304-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | Crystax Pharmaceuticals S.L. (ES) | 2006-08-09 | — | — | EP | claimed |
| WO-2005054236-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | CRYSTAX PHARMACEUTICALS S.L. (ES) | 2005-06-16 | — | — | WO | claimed |
| US-20240293366-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AZORA THERAPEUTICS, INC. | 2024-09-05 | — | — | US | disclosed |
| CN-117683030-A | Baiphylline derivative containing acylhydrazone structure, and preparation method and application thereof | 南开大学 | 2024-03-12 | — | — | CN | disclosed |
| EP-4252844-A2 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AZORA THERAPEUTICS, INC. (US) | 2023-10-04 | — | — | EP | disclosed |
| CN-114206312-A | Topical compositions and methods for treating inflammatory skin disorders | 阿佐拉治疗股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| US-20220023259-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AZORA THERAPEUTICS, INC. | 2022-01-27 | — | — | US | disclosed |
| US-11154533-B2 | Topical compositions and methods for treating inflammatory skin diseases | AZORA THERAPEUTICS, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20210186931-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AZORA THERAPEUTICS, INC. | 2021-06-24 | — | — | US | disclosed |
| US-20100331355-A1 | Substituted Quinolines for the Treatment of Cancer | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2010-12-30 | — | — | US | disclosed |
| EP-1687304-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | Crystax Pharmaceuticals S.L. (ES) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005054236-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | CRYSTAX PHARMACEUTICALS S.L. (ES) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210186931-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AHR, ARNT, TLR8 | DYRK1A 859/4885TERT 2599/4885TP53 1820/4885 |
| US-11154533-B2 | Topical compositions and methods for treating inflammatory skin diseases | AHR, ARNT, TLR8 | DYRK1A 859/4885TERT 2599/4885TP53 1820/4885 |
| US-20100331355-A1 | Substituted Quinolines for the Treatment of Cancer | TOP2B, TOP1, TOP2A | DYRK1A 3740/4885TERT 1447/4885TP53 557/4885 |
| US-20240293366-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AHR, ARNT, TLR8 | DYRK1A 859/4885TERT 2599/4885TP53 1820/4885 |
| US-20220023259-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AHR, ARNT, TLR8 | DYRK1A 859/4885TERT 2599/4885TP53 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.