Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.79 |
| ▸ | IKBKB | O14920 | 10/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.65 |
| ▸ | CHUK | O15111 | 2/20 | 0.63 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | DKK1 | O94907 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518338 | 0.89 | JAK2 (0.82) | JAK2IKBKBMAPK8MAPK10CHUK | |
| SCHEMBL3521591 | 0.88 | JAK2 (1.00) | JAK2IKBKBMAPK8MAPK10CHUK | |
| SCHEMBL7476832 | 0.83 | JAK2 (0.72) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL15212479 | 0.83 | JAK2 (0.76) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL10192774 | 0.83 | JAK2 (0.69) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL4383450 | 0.82 | JAK2 (1.00) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL3522413 | 0.82 | IKBKB (0.69) | JAK2IKBKBMAPK8MAPK10CHUK | |
| SCHEMBL10346581 | 0.82 | JAK2 (0.70) | JAK2IKBKBMAPK8MAPK10CHUK | |
| SCHEMBL3518049 | 0.81 | IKBKB (0.79) | JAK2IKBKBMAPK8MAPK10CHUK | |
| SCHEMBL13555628 | 0.81 | JAK2 (0.72) | JAK2IKBKBCHUKJAK3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | JAK2 341/4885IKBKB 3246/4885MAPK8 3605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.