Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.64 |
| ▸ | CHUK | O15111 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.61 |
| ▸ | CDK4 | P11802 | 5/20 | 0.60 |
| ▸ | KDR | P35968 | 4/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212479 | 0.90 | JAK2 (0.76) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL7465716 | 0.87 | ACVR1 (0.70) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL4383450 | 0.84 | JAK2 (1.00) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL10346581 | 0.84 | JAK2 (0.70) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL3518573 | 0.83 | JAK2 (0.79) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL660308 | 0.83 | JAK2 (0.69) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL13555628 | 0.83 | JAK2 (0.72) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL10192774 | 0.83 | JAK2 (0.69) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL23276819 | 0.82 | JAK2 (0.66) | JAK2IKBKBCHUKCDK2CCNE1 | |
| SCHEMBL7469627 | 0.82 | CDK2 (0.64) | JAK2IKBKBCHUKCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |