Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.76 |
| ▸ | CDK4 | P11802 | 3/20 | 0.66 |
| ▸ | GSK3B | P49841 | 2/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | CCND3 | P30281 | 1/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.64 |
| ▸ | CHUK | O15111 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 3/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.61 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.61 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476832 | 0.90 | JAK2 (0.72) | JAK2CDK4GSK3BIKBKBCHUK | |
| SCHEMBL7465716 | 0.90 | ACVR1 (0.70) | JAK2CDK4GSK3BIKBKBCHUK | |
| SCHEMBL7466266 | 0.87 | CDK2 (0.63) | JAK2CDK4GSK3BIKBKBCHUK | |
| SCHEMBL28254694 | 0.86 | JAK2 (1.00) | JAK2JAK3KDRHDAC1HDAC6 | |
| SCHEMBL4383450 | 0.84 | JAK2 (1.00) | JAK2IKBKBCHUKJAK3HDAC1 | |
| SCHEMBL10346581 | 0.84 | JAK2 (0.70) | JAK2CDK4GSK3BIKBKBCHUK | |
| SCHEMBL3518573 | 0.83 | JAK2 (0.79) | JAK2GSK3BIKBKBCHUKJAK3 | |
| SCHEMBL13555628 | 0.83 | JAK2 (0.72) | JAK2CDK4GSK3BIKBKBCHUK | |
| SCHEMBL660308 | 0.83 | JAK2 (0.69) | JAK2CDK4GSK3BIKBKBCHUK | |
| SCHEMBL10192774 | 0.83 | JAK2 (0.69) | JAK2CDK4GSK3BIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817308-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-12-31 | — | — | EP | claimed |
| WO-2013126656-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-08-29 | — | — | WO | claimed |
| EP-2817308-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126656-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-08-29 | — | — | WO | disclosed |