Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.59 |
| ▸ | IKBKB | O14920 | 5/20 | 0.53 |
| ▸ | CDK2 | P24941 | 7/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | DKK1 | O94907 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.45 |
| ▸ | PRKCG | P05129 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518659 | 0.91 | IKBKB (0.52) | MTORIKBKBCDK2PIK3CAPIK3CG | |
| SCHEMBL3519335 | 0.90 | IKBKB (0.51) | MTORIKBKBCDK2PIK3CAPIK3CG | |
| SCHEMBL3520083 | 0.84 | IKBKB (0.61) | MTORIKBKBCDK2PIK3CAPIK3CG | |
| SCHEMBL4883123 | 0.83 | CAMKK2 (0.52) | IKBKBCDK2PIK3CAPIK3CGCDK4 | |
| SCHEMBL3524407 | 0.80 | IKBKB (0.71) | IKBKBGSK3BDKK1SMG1MAPK8 | |
| SCHEMBL3521925 | 0.80 | IKBKB (0.71) | IKBKBCDK2CDK4GSK3BDKK1 | |
| SCHEMBL3516749 | 0.78 | IKBKB (0.51) | IKBKBCDK2PIK3CAPIK3CGCDK1 | |
| SCHEMBL12801092 | 0.76 | CDK5 (0.71) | PIK3CAPIK3CGGSK3BJAK2FLT3 | |
| SCHEMBL4897612 | 0.76 | JAK2 (0.56) | IKBKBCDK2PIK3CAPIK3CGCDK4 | |
| SCHEMBL14254202 | 0.76 | JAK2 (0.53) | IKBKBCDK2PIK3CAPIK3CGJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| EP-1799652-A1 | N-BENZENESULFONYL SUBSTITUTED ANILINO-PYRIMIDINE ANALOGS | Wyeth (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006044457-A1 | N-BENZENESULFONYL SUBSTITUTED ANILINO-PYRIMIDINE ANALOGS | WYETH (US) | 2006-04-27 | — | — | WO | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | MTOR 2111/4885IKBKB 3246/4885CDK2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.