Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.65 |
| ▸ | THRB | P10828 | 9/20 | 0.65 |
| ▸ | RARB | P10826 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | RARA | P10276 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | MTOR | P42345 | 1/20 | 0.65 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327143 | 1.00 | THRA (0.65) | THRATHRBRARBMEN1KMT2A | |
| SCHEMBL13617729 | 1.00 | THRA (0.65) | THRATHRBRARBMEN1KMT2A | |
| SCHEMBL75644 | 1.00 | THRA (0.65) | THRATHRBRARBMEN1KMT2A | |
| SCHEMBL6835676 | 1.00 | THRA (0.65) | THRATHRBRARBMEN1KMT2A | |
| SCHEMBL4931942 | 1.00 | THRA (0.65) | THRATHRBRARBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11612075 | 0.98 | THRA (0.63) | THRATHRBRARBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30595523 | 0.98 | THRA (0.63) | THRATHRBRARBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11664844 | 0.98 | THRA (0.63) | THRATHRBRARBMEN1KMT2A | |
| SCHEMBL2677626 | 0.98 | RARB (0.64) | THRATHRBRARBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11612937 | 0.96 | RARB (0.62) | THRATHRBRARBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12415822-B2 | Small molecule inhibitors selective for polo-like kinase protein | UNIVERSITY OF SOUTH CAROLINA (US) | 2025-09-16 | — | — | US | disclosed |
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | UNIVERISTY OF SOUTH CAROLINA | 2024-01-25 | — | — | US | disclosed |
| US-11597737-B2 | Small molecule inhibitors selective for polo-like kinase proteins | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-03-07 | — | — | US | disclosed |
| US-20200399297-A1 | Small Molecule Inhibitors Selective for Polo-Like Kinase Proteins | UNIVERSITY OF SOUTH CAROLINA | 2020-12-24 | — | — | US | disclosed |
| US-20170283445-A1 | Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins | UNIVERSITY OF SOUTH CAROLINA | 2017-10-05 | — | — | US | disclosed |
| US-9708368-B2 | Linear peptide antibiotics | RQX PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9248467-B2 | Types of electrodeposited polymer coatings with reversible wettability and electro-optical properties | ADVINCULA RIGOBERTO (US) | 2016-02-02 | — | — | US | disclosed |
| US-8772327-B2 | Phenylpropionic acid derivative and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2014-07-08 | — | — | US | disclosed |
| US-8334314-B2 | Phenylpropionic acid derivative and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-12-18 | — | — | US | disclosed |
| US-20120015146-A1 | TYPES OF ELECTRODEPOSITED POLYMER COATINGS WITH REVERSIBLE WETTABILITY AND ELECTRO-OPTICAL PROPERTIES | THE UNIVERSITY OF HOUSTON SYSTEM (US) | 2012-01-19 | — | — | US | disclosed |
| US-20100093819-A1 | PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-04-15 | — | — | US | disclosed |
| US-6869951-B1 | Method of changing conformation of a matrix metalloproteinase | PHARMACIA CORPORATION (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040018458-A1 | Photothermographic material | FUJIFILM CORPORATION (JP) | 2004-01-29 | — | — | US | disclosed |
| WO-2002003994-A1 | N SULFONYL AMINOACID DERIVATIVES AS INHIBITORS OF METALLOPROTEINASE | G.D. SEARLE & CO. (US) | 2002-01-17 | — | — | WO | disclosed |
| WO-2001005389-A2 | N-SULFONYLAMINIACID DERIVATIVES AS INHIBITORS OF METALLOPRTEINASE | G.D. SEARLE & CO. (US) | 2001-01-25 | — | — | WO | disclosed |
| US-5223384-A | Multilayer; paper support, subbing and photosensitive layer | KONICA CORPORATION (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0256820-B1 | THERMAL DEVELOPING LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5032499-A | High density, stability | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1991-07-16 | — | — | US | disclosed |
| US-4792628-A | ANTIOXIDANTS, ANTIINFLAMMATORY AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283445-A1 | Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins | PLK2, PLK4, PLK3 | THRA 3862/4885THRB 3039/4885RARB 1539/4885 |
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | PLK2, PLK4, PLK3 | THRA 3808/4885THRB 3045/4885RARB 1435/4885 |
| US-20200399297-A1 | Small Molecule Inhibitors Selective for Polo-Like Kinase Proteins | PLK2, PLK4, PLK3 | THRA 3862/4885THRB 3039/4885RARB 1539/4885 |
| US-20100093819-A1 | PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF | PLA2G12A, PLA2G4A, PLA2G4B | THRA 3096/4885THRB 3188/4885RARB 2328/4885 |
| US-11597737-B2 | Small molecule inhibitors selective for polo-like kinase proteins | PLK2, PLK4, PLK3 | THRA 3862/4885THRB 3039/4885RARB 1539/4885 |
| US-12415822-B2 | Small molecule inhibitors selective for polo-like kinase protein | PLK2, PLK4, PLK3 | THRA 3808/4885THRB 3045/4885RARB 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.