Nitrazepam

Nitrazepam

SCHEMBL35202

O=C1CN=C(c2ccccc2)c2cc([N+](=O)[O-])ccc2N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 1.00
LMNA P02545 2/20 1.00
HPGD P15428 1/20 1.00
CHRM1 P11229 1/20 0.76
GABRA1 P14867 5/20 0.73
GABRA5 P31644 5/20 0.73
GABRA3 P34903 5/20 0.73
GABRA2 P47869 5/20 0.73
GABRG2 P18507 4/20 0.73
GABRB3 P28472 4/20 0.73
GABRB2 P47870 4/20 0.73
GABRP O00591 2/20 0.73
GABRD O14764 2/20 0.73
GABRB1 P18505 2/20 0.73
GABRA4 P48169 2/20 0.73
GABRE P78334 2/20 0.73
GABRA6 Q16445 2/20 0.73
GABRG1 Q8N1C3 2/20 0.73
GABRG3 Q99928 2/20 0.73
GABRQ Q9UN88 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitrazepam SCHEMBL29408437 1.00 PDE4D (1.00) PDE4DLMNAHPGDCHRM1GABRA1
Nitrazepam SCHEMBL9747297 1.00 PDE4D (1.00) PDE4DLMNAHPGDCHRM1GABRA1
Nitrazepam SCHEMBL28564999 0.93 PDE4D (0.87) PDE4DLMNAHPGDCHRM1GABRA1
SCHEMBL7721819 0.88 LMNA (0.78) PDE4DLMNAHPGDCHRM1GABRA1
SCHEMBL2615370 0.88 PDE4D (0.78) PDE4DLMNAHPGDCHRM1GABRA1
SCHEMBL13284399 0.88 LMNA (0.78) PDE4DLMNAHPGDCHRM1GABRA1
Nimetazepam SCHEMBL1003526 0.88 LMNA (0.81) PDE4DLMNAHPGDCHRM1GABRA1
SCHEMBL7322518 0.86 CHRM1 (1.00) PDE4DLMNAHPGDCHRM1GABRA1
Clonazepam SCHEMBL20771795 0.85 GABRA1 (0.96) PDE4DLMNAHPGDCHRM1GABRA1
Nitrazepam SCHEMBL31373270 0.84 LMNA (0.73) PDE4DLMNAHPGDCHRM1GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17684 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
US-20260137654-A1 COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER THE REGENTS OF THE UNIV OF CALIFORNIA (US) 2026-05-21 US claimed
US-12624036-B2 Method of treating post-traumatic stress disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
US-12624037-B2 Method of treating agitation, aggressive behavior, and impulse control disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
US-20260117775-A1 Water Pump COAVIS (KR) 2026-04-30 US claimed
US-20260083706-A1 5HT AGONISTS FOR TREATING DISORDERS UNIV CALIFORNIA (US) 2026-03-26 US claimed
US-20260076953-A1 METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2026-03-19 US claimed
EP-4696377-A2 5HT AGONISTS FOR TREATING DISORDERS The Regents of the University of California (US) 2026-02-18 EP claimed
EP-3507371-B1 COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM UNIV RUTGERS (US) 2026-01-28 EP claimed
EP-4684775-A1 ORAL SOLUTION COMPRISING NITRAZEPAM LABOMED PHARMACEUTICAL COMPANY S.A. (GR) 2026-01-28 EP claimed
EP-0216555-A2 Use of dioxopiperidine derivatives in the treatment of anxiety, for the reduction of chronic abnormally high brain levels of serotonin or 5-hydroxy-indoleacetic acid, and in the treatment of bacterial or viral infections BTG INTERNATIONAL LIMITED (GB) 1987-04-01 EP claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed
EP-0150721-A2 Drug Firma Paliz, Ziegler (CH) 1985-08-07 EP claimed
EP-0110955-A1 BRAIN-SPECIFIC DRUG DELIVERY. UNIV FLORIDA (US) 1984-06-20 EP claimed
US-4431742-A RADIOIMMUNOASSAY; INCUBATION OF LABELED DRUG USING PELLETS OF HOMOGENIZED BRAIN AS CARRIERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-02-14 US claimed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 WO claimed
US-4369172-A Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose FOREST LABORATORIES INC. (US) 1983-01-18 US claimed
US-4316897-A TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1982-02-23 US claimed
EP-0025546-A2 Therapeutical use of tranquillizing benzodiazepine derivatives and mixtures containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-03-25 EP claimed
US-4028467-A Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process BERGER FRANK M 1977-06-07 US claimed