Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.63 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.63 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.63 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | CCKBR | P32239 | 2/20 | 0.62 |
| ▸ | MC3R | P41968 | 1/20 | 0.62 |
| ▸ | GHSR | Q92847 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | GABRP | O00591 | 2/20 | 0.58 |
| ▸ | GABRD | O14764 | 2/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.58 |
| ▸ | GABRE | P78334 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flunitrazepam SCHEMBL28086646 | 0.93 | GABRA1 (0.75) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Clonazepam SCHEMBL17728660 | 0.90 | GABRA1 (0.67) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nimetazepam SCHEMBL29374297 | 0.90 | LMNA (1.00) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nimetazepam SCHEMBL79886 | 0.90 | LMNA (1.00) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nimetazepam SCHEMBL10689471 | 0.88 | LMNA (0.95) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nimetazepam SCHEMBL9542099 | 0.88 | LMNA (0.95) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nitrazepam SCHEMBL35202 | 0.88 | PDE4D (1.00) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nitrazepam SCHEMBL9747297 | 0.88 | PDE4D (1.00) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Nitrazepam SCHEMBL29408437 | 0.88 | PDE4D (1.00) | LMNAPDE4DHPGDGABRA1GABRG2 | |
| Flunitrazepam SCHEMBL8364961 | 0.86 | GABRA1 (0.64) | LMNAPDE4DHPGDGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593104-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | Müller, Prof. Dr., Wolfgang (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2011011692-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | STC.UNM (US) | 2011-01-27 | — | — | WO | disclosed |