Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35210914 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KDM4EERN1 | |
| SCHEMBL35211202 | 0.77 | MAP2K1 (0.35) | ALDH1A1 | |
| SCHEMBL22939106 | 0.76 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2ERN1 | |
| SCHEMBL2594904 | 0.75 | ERN1 (0.35) | ALDH1A1ERN1 | |
| SCHEMBL670294 | 0.74 | CYP2A6 (0.41) | ALDH1A1SMN1; SMN2KDM4EERN1 | |
| SCHEMBL35211188 | 0.73 | MAP2K1 (0.39) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL35210704 | 0.73 | NOTUM (0.37) | ALDH1A1KDM4E | |
| SCHEMBL19620973 | 0.73 | GABRA1 (0.33) | — | |
| SCHEMBL35210669 | 0.72 | PTPN11 (0.38) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL672866 | 0.71 | CYP2A6 (0.41) | ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | INCYTE CORP (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | CDK4, CCNA1, CCNO | ALDH1A1 577/4885SMN1; SMN2 3223/4885KDM4E 1827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.