SCHEMBL35211616

SCHEMBL35211616

COc1cnc(Br)c(Cl)n1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33
SIRT6 Q8N6T7 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CCR4 P51679 5/20 0.31
MPI P34949 1/20 0.31
CCR5 P51681 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11227327 0.77 NNMT (0.35) CHRNB2CHRNA4SIRT6KDM4EALDH1A1
SCHEMBL11223761 0.77 SIRT6 (0.33) SIRT6KDM4EALDH1A1SMN1; SMN2CCR4
SCHEMBL29299460 0.77 ALDH1A1 (0.33) SIRT6KDM4EALDH1A1SMN1; SMN2MPI
SCHEMBL31022760 0.77 POLB (0.36) CHRNB2CHRNA4SIRT6KDM4EALDH1A1
SCHEMBL13500438 0.77 POLB (0.36) CHRNB2CHRNA4SIRT6KDM4EALDH1A1
SCHEMBL25548420 0.76 NPC1 (0.38) KDM4EALDH1A1SMN1; SMN2CCR4
SCHEMBL1315972 0.75 SIRT6 (0.36) CHRNB2CHRNA4SIRT6ALDH1A1
SCHEMBL273776 0.75
SCHEMBL5106649 0.74 MAPKAPK2 (0.32) SIRT6ALDH1A1CCR4
SCHEMBL5106652 0.74 CCR4 (0.34) CCR4CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124205-A1 MODULATORS OF BETA CATENIN AND USES THEREOF DEWPOINT THERAPEUTICS INC (US) 2026-05-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124205-A1 MODULATORS OF BETA CATENIN AND USES THEREOF CTNNB1, CTNNA1, CTNND1 CHRNB2 820/4885CHRNA4 615/4885SIRT6 3164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.