Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521538 | 0.85 | DRD2 (0.49) | PGRDRD2DRD4HDAC4HDAC8 | |
| SCHEMBL3518712 | 0.69 | PGR (0.41) | PGRALDH1A1HRH4P2RX4 | |
| SCHEMBL3522080 | 0.69 | PGR (0.39) | PGRHDAC4HDAC8ALDH1A1GAA | |
| SCHEMBL21497997 | 0.64 | KDM4E (0.46) | PGRALDH1A1GAAP2RX4MAPT | |
| SCHEMBL11576201 | 0.63 | DRD2 (0.76) | DRD2DRD4HTTHTR2CHTR2A | |
| SCHEMBL1115811 | 0.62 | USP2 (0.41) | ALDH1A1GAAHTTMAPT | |
| SCHEMBL11576560 | 0.60 | SETD7 (0.76) | DRD2DRD4ALDH1A1HTTSETD7 | |
| SCHEMBL11575864 | 0.59 | MAOB (0.42) | ALDH1A1GAAMAOA | |
| SCHEMBL3520553 | 0.59 | PGR (0.75) | PGR | |
| SCHEMBL17079995 | 0.59 | PGR (0.40) | PGRP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| EP-1495030-B1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | PGR, PGRMC1, PGRMC2 | PGR 1/4885DRD2 2299/4885DRD4 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.