Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16078966 | 0.98 | HSD17B10 (0.52) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL9064233 | 0.91 | ACE2 (0.60) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL845511 | 0.89 | HSD17B10 (0.57) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL8305374 | 0.88 | HSD17B10 (0.50) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL8306633 | 0.88 | HSD17B10 (0.46) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL29860764 | 0.87 | HSD17B10 (0.55) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL16676988 | 0.85 | HSD17B10 (0.55) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL21922782 | 0.84 | ACE2 (0.58) | HSD17B10ANPEPERAP2ALDH1A1ALOX15 | |
| SCHEMBL17785970 | 0.83 | ACE2 (0.50) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 | |
| SCHEMBL6051874 | 0.83 | ACE2 (0.52) | HSD17B10ANPEPERAP2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891943-B | Method for producing mixtures of linear and non-linear ethyleneamines | 诺力昂化学品国际有限公司 | 2023-09-22 | — | — | CN | claimed |
| CN-110891943-A | Process for preparing mixtures of linear and nonlinear ethyleneamines | 诺力昂化学品国际有限公司 | 2020-03-17 | — | — | CN | claimed |
| CN-110891943-B | Method for producing mixtures of linear and non-linear ethyleneamines | 诺力昂化学品国际有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-110997659-B | Process for preparing propylene amine and propylene amine derivatives | 诺力昂化学品国际有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-110831922-B | Method for producing chain-extended hydroxyethylethyleneamines, ethyleneamines or mixtures thereof | 诺力昂化学品国际有限公司 | 2022-12-23 | — | — | CN | disclosed |
| EP-3596039-B1 | PROCESS FOR MANUFACTURING CHAIN-EXTENDED HYDROXYETHYLETHYLENEAMINES, ETHYLENEAMINES, OR MIXTURES THEREOF | NOURYON CHEMICALS INT BV (NL) | 2021-05-05 | — | — | EP | disclosed |
| US-10995077-B2 | Process to prepare higher ethylene amines and ethylene amine derivatives | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2021-05-04 | — | — | US | disclosed |
| US-20200131136-A1 | PROCESS FOR MANUFACTURING CHAIN-EXTENDED HYDROXYETHYLETHYLENEAMINES, ETHYLENEAMINES, OR MIXTURES THEREOF | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2020-04-30 | — | — | US | disclosed |
| CN-110997659-A | Process for preparing propyleneamine and propyleneamine derivatives | 诺力昂化学品国际有限公司 | 2020-04-10 | — | — | CN | disclosed |
| CN-110891943-A | Process for preparing mixtures of linear and nonlinear ethyleneamines | 诺力昂化学品国际有限公司 | 2020-03-17 | — | — | CN | disclosed |
| US-20190047971-A1 | PROCESS TO PREPARE HIGHER ETHYLENE AMINES AND ETHYLENE AMINE DERIVATIVES | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2019-02-14 | — | — | US | disclosed |
| WO-2017137530-A1 | PROCESS TO PREPARE HIGHER ETHYLENE AMINES AND ETHYLENE AMINE DERIVATIVES | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2017-08-17 | — | — | WO | disclosed |
| WO-2016130968-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | YALE UNIVERSITY (US) | 2016-08-18 | — | — | WO | disclosed |
| US-7659279-B2 | 2-{(2S)-2-[({4-[3-Chloro-4-fluoroanilino]-7-methoxyquinazolin-5-yl}oxy)methyl]pyrrolidin-1-yl}-2-oxoethanol; epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors; breast, colorectal and head and neck cancer | ASTRAZENECA AB (SE) | 2010-02-09 | — | — | US | disclosed |
| EP-1622620-B1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| US-20060211714-A1 | Quinazoline derivatives and their use in the treatment of cancer | ASTRAZENECA AB (SE) | 2006-09-21 | — | — | US | disclosed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-4946612-A | Lubricating oil composition for sliding surface and for metallic working and method for lubrication of machine tools using said composition | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1990-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995077-B2 | Process to prepare higher ethylene amines and ethylene amine derivatives | H1-5, H1-4, PNMT | HSD17B10 4085/4885ANPEP 407/4885ERAP2 673/4885 |
| US-20190047971-A1 | PROCESS TO PREPARE HIGHER ETHYLENE AMINES AND ETHYLENE AMINE DERIVATIVES | H1-5, H1-4, PNMT | HSD17B10 4085/4885ANPEP 407/4885ERAP2 673/4885 |
| US-20200131136-A1 | PROCESS FOR MANUFACTURING CHAIN-EXTENDED HYDROXYETHYLETHYLENEAMINES, ETHYLENEAMINES, OR MIXTURES THEREOF | HNMT, PNMT, HRH2 | HSD17B10 1858/4885ANPEP 512/4885ERAP2 580/4885 |
| US-20060211714-A1 | Quinazoline derivatives and their use in the treatment of cancer | EGFR, ERBB2, ERBB4 | HSD17B10 4735/4885ANPEP 1580/4885ERAP2 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.