Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871312 | 0.89 | GFER (0.43) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL12061623 | 0.86 | MAPT (0.67) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL12004260 | 0.84 | MAPT (0.69) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL27418887 | 0.77 | MAPT (0.43) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL30634161 | 0.76 | MAPT (0.50) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL3111834 | 0.76 | MAPT (0.50) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL12480160 | 0.74 | KDM4E (0.47) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL12479882 | 0.74 | KDM4E (0.47) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL8526314 | 0.74 | DRD2 (0.53) | KDM4EMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL5913481 | 0.73 | PARP1 (0.46) | KDM4EMAPTALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| CN-100404508-C | Tetrahydroquinoline derivatives | AKZO NOBEL NV (NL) | 2008-07-23 | — | — | CN | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
| CN-1729175-A | Tetrahydroquinoline derivatives | AKZO NOBEL NV (NL) | 2006-02-01 | — | — | CN | disclosed |
| EP-1578726-A2 | TETRAHYDROQUINOLINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056780-A2 | TETRAHYDROQUINOLINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | KDM4E 394/4885MAPT 4864/4885ALDH1A1 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.