Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.61 |
| ▸ | DKK1 | O94907 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 5/20 | 0.58 |
| ▸ | CDK4 | P11802 | 3/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14020998 | 0.84 | MAPK8 (0.59) | IKBKBGSK3BCDK2CDK4MAPK8 | |
| SCHEMBL3521197 | 0.83 | IKBKB (0.71) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL3518049 | 0.82 | IKBKB (0.79) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL27446674 | 0.81 | PLK1 (0.53) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL3520305 | 0.80 | IKBKB (0.70) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL3519410 | 0.77 | IKBKB (0.79) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL3255412 | 0.77 | IKBKB (0.59) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL11264019 | 0.76 | IKBKB (0.66) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL3520123 | 0.76 | IKBKB (0.74) | IKBKBDKK1GSK3BMAPK8MAPK10 | |
| SCHEMBL14263719 | 0.76 | DKK1 (0.66) | IKBKBDKK1GSK3BMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | IKBKB 3246/4885DKK1 2975/4885GSK3B 2108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.