Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10769887 | 0.86 | HTR2A (0.54) | SIGMAR1LMNAKMT2ACYP2C9CYP2C19 | |
| SCHEMBL10421314 | 0.86 | HTR2A (0.54) | SIGMAR1LMNAKMT2ACYP2C9CYP2C19 | |
| SCHEMBL25517308 | 0.82 | ACACB (0.48) | SIGMAR1LMNACYP2C9HTR2ASOST | |
| SCHEMBL23451040 | 0.81 | ACACB (0.53) | KMT2ACYP2C9CYP2C19CYP2D6FFAR1 | |
| SCHEMBL25542628 | 0.81 | SIGMAR1 (0.44) | SIGMAR1KMT2ACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL26161774 | 0.78 | CYP2D6 (0.50) | SIGMAR1KMT2ACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL23442359 | 0.78 | CYP2D6 (0.44) | SIGMAR1KMT2ACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL10421320 | 0.78 | LMNA (0.42) | SIGMAR1LMNAKMT2AHTR2AFFAR1 | |
| SCHEMBL10421315 | 0.76 | CYP1A2 (0.48) | SIGMAR1LMNAKMT2ACYP2C9CYP2C19 | |
| SCHEMBL10769885 | 0.76 | SIGMAR1 (0.53) | SIGMAR1LMNAKMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709473-B2 | Substituted 2H-[1,2,4]triazolo[4,3-a]pyrazines as GSK-3 inhibitors | PFIZER INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070249612-A1 | Substituted 2H-[1,2,4]Triazolo[4,3-A]Pyrazines as Gsk-3 Inhibitors | BENBOW JOHN W | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249612-A1 | Substituted 2H-[1,2,4]Triazolo[4,3-A]Pyrazines as Gsk-3 Inhibitors | GSK3B, GSK3A, GSKIP | SIGMAR1 1017/4885LMNA 2096/4885KMT2A 822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.