Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 11/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531277 | 0.83 | CYP1A2 (0.42) | ENPP2HSP90AA1KDRMAPK1 | |
| SCHEMBL3536349 | 0.81 | ENPP2 (0.59) | ENPP2TMPRSS2HSP90AA1KDRPDGFRB | |
| SCHEMBL3530929 | 0.80 | ENPP2 (0.46) | ENPP2HSP90AA1KDRPDGFRB | |
| SCHEMBL3531014 | 0.78 | KDR (0.47) | HSP90AA1KDRPDGFRB | |
| SCHEMBL3531012 | 0.77 | HSP90AA1 (0.42) | ENPP2HSP90AA1KDR | |
| SCHEMBL3528455 | 0.76 | POLB (0.41) | ENPP2TMPRSS2MAPK10KDRPDGFRB | |
| SCHEMBL3528264 | 0.75 | CYP1A2 (0.52) | ENPP2KDRPDGFRBMAPK1 | |
| SCHEMBL3530466 | 0.73 | ENPP2 (0.46) | ENPP2HSP90AA1KDRPDGFRB | |
| SCHEMBL3531023 | 0.72 | ENPP2 (0.46) | ENPP2HSP90AA1KDRPDGFRBMAPK1 | |
| SCHEMBL3536364 | 0.72 | PDGFRB (0.48) | ENPP2HSP90AA1KDRPDGFRBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662828-B2 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2010-02-16 | — | — | US | claimed |