Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.59 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528207 | 0.81 | ENPP2 (0.43) | ENPP2TMPRSS2PDGFRBKDRHSP90AA1 | |
| SCHEMBL3528455 | 0.80 | POLB (0.41) | ENPP2TMPRSS2PDGFRBGAAKDR | |
| SCHEMBL3530929 | 0.77 | ENPP2 (0.46) | ENPP2PDGFRBKDRHSP90AA1 | |
| SCHEMBL3529127 | 0.76 | ENPP2 (0.55) | ENPP2TMPRSS2PDGFRBKDRHSP90AA1 | |
| SCHEMBL3532235 | 0.76 | L3MBTL1 (0.48) | ENPP2TMPRSS2LMNAPOLB | |
| SCHEMBL3531023 | 0.74 | ENPP2 (0.46) | ENPP2PDGFRBKDRHSP90AA1 | |
| SCHEMBL3530466 | 0.74 | ENPP2 (0.46) | ENPP2PDGFRBKDRLMNAHSP90AA1 | |
| SCHEMBL21656903 | 0.73 | ENPP2 (0.61) | ENPP2PDGFRBKDRNOTUMHSP90AA1 | |
| SCHEMBL3531326 | 0.73 | PDGFRB (0.60) | ENPP2PDGFRBKDR | |
| SCHEMBL3528741 | 0.72 | CYP3A4 (0.53) | PDGFRBKDRLMNAPOLBHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662828-B2 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2010-02-16 | — | — | US | claimed |