Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529483 | 0.81 | CYP1A2 (0.47) | POLBLMNASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3536349 | 0.80 | ENPP2 (0.59) | POLBLMNATMPRSS2GAAENPP2 | |
| SCHEMBL3532235 | 0.79 | L3MBTL1 (0.48) | POLBLMNAHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL5545020 | 0.77 | KDR (0.47) | SMN1; SMN2ALDH1A1KDRPDGFRBNPC1 | |
| SCHEMBL3528207 | 0.76 | ENPP2 (0.43) | MAPK1TMPRSS2ENPP2MAPK10KDR | |
| SCHEMBL3530813 | 0.74 | KDR (0.55) | HPGDSMN1; SMN2MAPK1KMT2AMEN1 | |
| SCHEMBL3530577 | 0.73 | MAPT (0.48) | MAPK1KMT2AMEN1KDRPDGFRB | |
| SCHEMBL3529849 | 0.72 | POLB (0.46) | POLBLMNAKMT2AALDH1A1KDM4E | |
| SCHEMBL3530929 | 0.72 | ENPP2 (0.46) | ENPP2KDRPDGFRBNPC1RAB9A | |
| SCHEMBL3532982 | 0.70 | CYP1A2 (0.52) | SMN1; SMN2MAPK1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662828-B2 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2010-02-16 | — | — | US | claimed |