Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3530868 | 0.86 | HSD11B1 (0.43) | HSD11B1CYP3A4TP53MAPTPTGS1 | |
| SCHEMBL3531866 | 0.83 | HSD11B1 (0.40) | HSD11B1CYP3A4TP53MAPTPTGS1 | |
| SCHEMBL3530986 | 0.81 | MEN1 (0.47) | HSD11B1PTGS2MEN1KMT2ACCR3 | |
| SCHEMBL3531667 | 0.79 | HSD11B1 (0.38) | HSD11B1MEN1KMT2A | |
| SCHEMBL3529353 | 0.78 | HSD11B1 (0.38) | HSD11B1TP53MAPT | |
| SCHEMBL3533087 | 0.73 | MCHR1 (0.33) | HSD11B1HTR7 | |
| SCHEMBL3527433 | 0.72 | HSD11B1 (0.41) | HSD11B1MAPTPTGS1PTGS2MEN1 | |
| SCHEMBL3528063 | 0.71 | HSD11B1 (0.38) | HSD11B1PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL3530319 | 0.71 | HSD11B1 (0.42) | HSD11B1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL3532268 | 0.69 | CCR3 (0.41) | HSD11B1CYP3A4MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652057-B2 | Pyrazolones as 11b-HSD1 inhibitors for diabetes | HOFFMAN-LA ROCHE INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | HSD11B1, HSD17B1, HSD17B7 | HSD11B1 1/4885CYP3A4 45/4885TP53 3775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.