Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1466735 | 1.00 | LTA4H (0.36) | LTA4HMAPTATMCHRNB2CHRNB4 | |
| SCHEMBL1467148 | 1.00 | LTA4H (0.36) | LTA4HMAPTATMCHRNB2CHRNB4 | |
| SCHEMBL9330121 | 0.97 | CHRNB2 (0.38) | LTA4HMAPTATMCHRNB2CHRNB4 | |
| SCHEMBL8782038 | 0.89 | MEN1 (0.30) | MEN1KMT2ALMNA | |
| SCHEMBL23872300 | 0.86 | LTA4H (0.42) | LTA4HMAPTATMCHRNB2CHRNB4 | |
| SCHEMBL10748748 | 0.83 | HRH3 (0.43) | LTA4HMAPTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7227482 | 0.83 | HRH3 (0.43) | LTA4HMAPTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL23872301 | 0.83 | HRH3 (0.43) | LTA4HMAPTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3532703 | 0.78 | KDM4E (0.45) | GAAALDH1A1POLB | |
| SCHEMBL1467290 | 0.78 | KDM4E (0.45) | GAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |