Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1467291 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL1467290 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL10748084 | 0.88 | KDM4E (0.44) | KDM4EALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL10748936 | 0.88 | KDM4E (0.44) | KDM4EALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL8782038 | 0.83 | MEN1 (0.30) | — | |
| SCHEMBL21872268 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL3750098 | 0.79 | USP2 (0.43) | KDM4EALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL1467148 | 0.78 | LTA4H (0.36) | ALDH1A1POLBGAA | |
| SCHEMBL3531020 | 0.78 | LTA4H (0.36) | ALDH1A1POLBGAA | |
| SCHEMBL1466735 | 0.78 | LTA4H (0.36) | ALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |