Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TET3 | O43151 | 3/20 | 0.45 |
| ▸ | FBXL19 | Q6PCT2 | 3/20 | 0.45 |
| ▸ | CXXC5 | Q7LFL8 | 3/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.45 |
| ▸ | CXXC4 | Q9H2H0 | 3/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.45 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17707495 | 0.90 | OPRM1 (0.47) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL12162991 | 0.87 | USP2 (0.53) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL704090 | 0.84 | KMT2A (0.41) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL702270 | 0.84 | CYP3A4 (0.41) | KMT2AOPRM1HSD11B1MEN1ALDH1A1 | |
| SCHEMBL16554092 | 0.82 | MEN1 (0.36) | KMT2AOPRM1MEN1ALDH1A1LMNA | |
| SCHEMBL20004189 | 0.81 | APP (0.54) | OPRM1ALDH1A1TSHR | |
| SCHEMBL442118 | 0.79 | TSHR (0.54) | TSHR | |
| SCHEMBL568885 | 0.79 | MEN1 (0.41) | KMT2AOPRM1MEN1ALDH1A1AKR1C1 | |
| SCHEMBL10478279 | 0.79 | OPRM1 (0.55) | KMT2AOPRM1ALDH1A1LMNATSHR | |
| SCHEMBL13689912 | 0.78 | MEN1 (0.56) | KMT2AMEN1SMN1; SMN2NPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20060229336-A1 | Ccr5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORPORATION | 2006-10-12 | — | — | US | disclosed |
| EP-1569646-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054974-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229336-A1 | Ccr5 antagonists as therapeutic agents | CCR5, CCR1, CXCR3 | KMT2A 4565/4885TET3 4245/4885FBXL19 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.