Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | BACE1 | P56817 | 4/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | PARK7 | Q99497 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529672 | 0.93 | HSD11B1 (0.45) | HSD11B1CYP3A4ALDH1A1KMT2AADRA1D | |
| SCHEMBL3531778 | 0.90 | HSD11B1 (0.44) | HSD11B1CYP3A4ACHEBACE1BCHE | |
| SCHEMBL3531092 | 0.87 | HSD11B1 (0.41) | HSD11B1CYP3A4MEN1ALDH1A1KMT2A | |
| SCHEMBL3535175 | 0.83 | KDM4E (0.42) | HSD11B1CYP3A4MEN1ALDH1A1GAA | |
| SCHEMBL3533983 | 0.81 | HSD11B1 (0.36) | HSD11B1CYP3A4ALDH1A1ADRA1DADRA1A | |
| SCHEMBL3531568 | 0.80 | HSD11B1 (0.61) | HSD11B1CYP3A4GRM5ACHEBACE1 | |
| SCHEMBL3535544 | 0.80 | HSD11B1 (0.56) | HSD11B1CYP3A4GRM5ACHEBACE1 | |
| SCHEMBL3526622 | 0.80 | HSD11B1 (0.36) | HSD11B1CYP3A4PARK7ADRA1DADRA1A | |
| SCHEMBL3526700 | 0.78 | KDM4E (0.39) | HSD11B1CYP3A4SIGMAR1ALDH1A1ADRA1D | |
| SCHEMBL3535358 | 0.77 | HSD11B1 (0.38) | HSD11B1CYP3A4PARK7ALDH1A1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652057-B2 | Pyrazolones as 11b-HSD1 inhibitors for diabetes | HOFFMAN-LA ROCHE INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | HSD11B1, HSD17B1, HSD17B7 | HSD11B1 1/4885CYP3A4 45/4885GRM5 3597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.