SCHEMBL353139

SCHEMBL353139

CN(C)C(=O)c1ccncc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.60
KMT2A Q03164 3/20 0.60
ALDH1A1 P00352 3/20 0.54
HPGD P15428 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
NAPRT Q6XQN6 1/20 0.52
HTT P42858 1/20 0.52
LMNA P02545 3/20 0.51
HSD17B10 Q99714 3/20 0.49
MLYCD O95822 1/20 0.47
ALOX15 P16050 1/20 0.47
MEN1 O00255 2/20 0.46
CDC7 O00311 1/20 0.46
DBF4 Q9UBU7 1/20 0.46
TP53 P04637 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP3A4 P08684 2/20 0.45
CYP2C19 P33261 2/20 0.45
MPO P05164 1/20 0.45
ADORA3 P0DMS8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5796679 0.98 KDM4E (0.58) KDM4EKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL18924446 0.87 HDAC1 (0.53) KDM4EKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL10725189 0.84 KDM4E (0.58) KDM4EKMT2AALDH1A1NAPRTHTT
SCHEMBL19076162 0.82 KDM1A (0.59) KDM4EKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL11590778 0.82 KDM4E (0.56) KDM4EKMT2AALDH1A1NAPRTHTT
SCHEMBL1004649 0.82 ALDH1A1 (0.73) KDM4EKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL23882806 0.81 CYP3A4 (0.47) KDM4EKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL29123175 0.80 KDM4E (0.82) KDM4EKMT2AALDH1A1SMN1; SMN2NAPRT
SCHEMBL13036142 0.79 KDM4E (0.53) KDM4EKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL14855163 0.79 KDM4E (0.53) KDM4EKMT2AALDH1A1SMN1; SMN2NAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 316 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101065358-B 3-arylamino pyridine derivatives MERCK SERONO SA 2015-03-11 CN claimed
CN-103408486-A Preparation method of 4-pyridinemethanol UNIV GUILIN TECH GUT 2013-11-27 CN claimed
EP-1802579-B1 Derivatives of 3-arylaminopyridine MERCK SERONO SA (CH) 2013-11-20 EP claimed
EP-2308874-A1 Useful beta-lactamase inhibitors Basilea Pharmaceutica AG (CH) 2011-04-13 EP claimed
CN-101065358-A 3-arylamino pyridine derivatives APPLIED RESEARCH SYSTEMS (AN) 2007-10-31 CN claimed
US-5939568-A Accelerated catalysis of olefinic epoxidations THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
WO-1998033786-A9 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS 1998-12-30 WO claimed
US-5846990-A Substituted biphenyl isoxazole sulfonamides BRISTOL-MYERS SQUIBB CO. (US) 1998-12-08 US claimed
WO-1998033786-A1 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 1998-08-06 WO claimed
US-5387631-A A dinitro-, diaminoalkane rubber component; rebound resilience, skid resistance and fuel savings THE YOKOHAMA RUBBER CO., LTD. (JP) 1995-02-07 US claimed
US-5017636-A Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-21 US claimed
US-4894409-A BLEND OR AMINO GROUP CONTAINING DIENE POLYMER AND SILICA FILLER NONCRACKING, WEAR RESISTANCE JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1990-01-16 US claimed
US-4822844-A MODIFIED WITH NITROGEN COMPOUND CONTAINING EITHER OXYGEN OR SULFUR AS BRANCHING OR END GROUP THE YOKOHAMA RUBBER CO., LTD. (JP) 1989-04-18 US claimed
US-4647625-A Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1987-03-03 US claimed
US-4616069-A REACTING THE ALKALI METAL OR ALKALINE EARTH METAL TERMINATED POLYMER WITH TIN COMPOUND AND ORGANIC COMPOUND HAVING AMIDE OR THIOAMIDE LINKAGES NIPPON ZEON CO., LTD. (JP) 1986-10-07 US claimed
EP-3858877-B1 POLYFUNCTIONAL VINYL AROMATIC COPOLYMER AND METHOD FOR MANUFACTURING SAME, COPOLYMER RUBBER OBTAINED THEREFROM, RUBBER COMPOSITION, RUBBER CROSSLINKED MATERIAL, AND TIRE MEMBER NIPPON STEEL CHEMICAL & MAT CO LTD (JP) 2026-05-27 EP disclosed
EP-4725942-A1 COMPOUNDS ACTIVE ON CYCLIN D1 PATHWAY AND THEIR USE Sibylla Biotech S.p.A. (IT) 2026-04-15 EP disclosed
US-4313945-A 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping CIBA-GEIGY CORPORATION (US) 1982-02-02 US disclosed
US-4297488-A 7-α-Methoxy cephalosporins MERCK & CO., INC. (US) 1981-10-27 US disclosed
US-4021429-A NIOBIUM OR TANTALUM COMPLEXES; OXYGEN-MOISTURE-FREE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-05-03 US disclosed