Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.71 |
| ▸ | FLT1 | P17948 | 2/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.58 |
| ▸ | ITK | Q08881 | 2/20 | 0.56 |
| ▸ | CLK2 | P49760 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | WNT1 | P04628 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | CLK3 | P49761 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534644 | 0.89 | FGFR1 (0.71) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL3542692 | 0.89 | PDPK1 (0.56) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL3541234 | 0.86 | ITK (0.71) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL3533024 | 0.84 | PDPK1 (0.73) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL3532319 | 0.84 | PDPK1 (0.51) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL3539728 | 0.84 | KDM4E (0.58) | PDPK1FGFR1FLT1CHEK1CLK2 | |
| SCHEMBL311148 | 0.84 | FGFR1 (1.00) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL29714859 | 0.84 | FGFR1 (1.00) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL3537965 | 0.83 | ITK (0.76) | PDPK1FGFR1FLT1CHEK1ITK | |
| SCHEMBL4989411 | 0.83 | PDPK1 (0.71) | PDPK1FGFR1FLT1CHEK1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | PDPK1 1862/4885FGFR1 886/4885FLT1 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.