Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | ITK | Q08881 | 5/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.45 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.45 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951667 | 0.88 | MAP3K8 (0.51) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3534395 | 0.84 | PDPK1 (0.72) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3537973 | 0.84 | PDPK1 (0.51) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3531870 | 0.84 | PDPK1 (0.71) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3537073 | 0.84 | FGFR1 (0.71) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3542692 | 0.83 | PDPK1 (0.56) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL5952153 | 0.82 | ITK (0.55) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3538345 | 0.82 | PDPK1 (0.72) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3538485 | 0.82 | PDPK1 (0.51) | PDPK1FGFR1FLT1ITKFLT3 | |
| SCHEMBL3539728 | 0.79 | KDM4E (0.58) | PDPK1FGFR1FLT1FLT3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
| US-20030207883-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | PDPK1 1862/4885FGFR1 886/4885FLT1 2793/4885 |
| US-20030207883-A1 | Indazole benzimidazole compounds | SLCO1B3, SLCO1B1, SLCO4C1 | PDPK1 1896/4885FGFR1 2175/4885FLT1 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.