Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535509 | 0.98 | MEN1 (0.97) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL11269804 | 0.97 | MEN1 (0.93) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL10746273 | 0.83 | MEN1 (0.71) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL11595466 | 0.82 | MEN1 (0.69) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL23723002 | 0.81 | KMT2A (0.71) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL31747051 | 0.81 | KMT2A (0.71) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL1968898 | 0.80 | MEN1 (0.67) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL11591539 | 0.80 | MEN1 (0.67) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL14150887 | 0.76 | MEN1 (0.61) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL2306226 | 0.76 | MEN1 (0.61) | MEN1KMT2AALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652057-B2 | Pyrazolones as 11b-HSD1 inhibitors for diabetes | HOFFMAN-LA ROCHE INC. (US) | 2010-01-26 | — | — | US | disclosed |
| EP-1924562-A2 | PYRAZOLONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025880-A2 | PYRAZOLONE DERIVATIVES AS 11-BETA HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | US | disclosed |
| US-4124373-A | Tetrahydroindazole herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | HSD11B1, HSD17B1, HSD17B7 | MEN1 1683/4885KMT2A 4086/4885ALDH1A1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.