Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 16/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 15/20 | 0.66 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.56 |
| ▸ | S100B | P04271 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.50 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13559445 | 0.98 | L3MBTL3 (0.68) | L3MBTL3L3MBTL1MBTD1S100BMEN1 | |
| SCHEMBL310165 | 0.86 | L3MBTL1 (0.60) | L3MBTL3L3MBTL1MBTD1S100BMEN1 | |
| SCHEMBL10290706 | 0.86 | L3MBTL1 (0.60) | L3MBTL3L3MBTL1MBTD1S100BMEN1 | |
| SCHEMBL30631754 | 0.86 | L3MBTL3 (0.60) | L3MBTL3L3MBTL1MBTD1S100BMEN1 | |
| SCHEMBL2892556 | 0.85 | L3MBTL1 (0.49) | L3MBTL3L3MBTL1MBTD1S100BMEN1 | |
| SCHEMBL23122819 | 0.84 | MAPT (0.54) | L3MBTL3L3MBTL1MBTD1ALDH1A1GAA | |
| SCHEMBL29745213 | 0.84 | LGMN (0.54) | L3MBTL3L3MBTL1MBTD1MAPTALOX15 | |
| SCHEMBL15283474 | 0.84 | L3MBTL3 (0.62) | L3MBTL3L3MBTL1MBTD1S100BMEN1 | |
| SCHEMBL23122811 | 0.84 | LGMN (0.54) | L3MBTL3L3MBTL1MBTD1MAPTALOX15 | |
| SCHEMBL29745199 | 0.84 | MAPT (0.54) | L3MBTL3L3MBTL1MBTD1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
| EP-1401831-A1 | INDAZOLE BENZIMIDAZOLE COMPOUNDS AS TYROSINE AND SERINE/THREONINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2004-03-31 | — | — | EP | disclosed |
| US-20030207883-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2003-11-06 | — | — | US | disclosed |
| WO-2003004488-A1 | INDAZOLE BENZIMIDAZOLE COMPOUNDS AS TYROSINE AND SERINE/THREONINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | L3MBTL3 854/4885L3MBTL1 663/4885MBTD1 2871/4885 |
| US-20030207883-A1 | Indazole benzimidazole compounds | SLCO1B3, SLCO1B1, SLCO4C1 | L3MBTL3 4080/4885L3MBTL1 4195/4885MBTD1 1243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.