Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RORC | P51449 | 9/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130616 | 0.91 | RORC (0.70) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL25394310 | 0.81 | MAPT (0.71) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL3531201 | 0.80 | KDM4E (0.53) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL8310013 | 0.78 | MAPT (0.80) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL23200368 | 0.77 | KCNMA1 (0.58) | KMT2AMEN1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7010635 | 0.76 | KCNMA1 (0.57) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6815263 | 0.76 | MAPT (0.60) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL18563891 | 0.76 | MAPT (0.77) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL11528824 | 0.76 | SMN1; SMN2 (0.56) | MAPTKMT2AMEN1TP53ALDH1A1 | |
| SCHEMBL8393663 | 0.76 | RORC (0.58) | MAPTKMT2AMEN1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| CN-1391562-A | Quinazoline derivatives as medicaments | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |