Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 10/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PTGIS | Q16647 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3534828 | 0.99 | CYP11B2 (0.59) | CYP11B2CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL3539978 | 0.75 | CYP11B2 (0.97) | CYP11B2TBXAS1CYP11B1 | |
| SCHEMBL3540598 | 0.71 | CYP11B2 (0.65) | CYP11B2TBXAS1GSK3BCDK8PTGS1 | |
| Hydrochloric Acid SCHEMBL3535788 | 0.70 | CYP11B2 (0.63) | CYP11B2TBXAS1GSK3BCDK8PTGS1 | |
| SCHEMBL21323991 | 0.70 | CYP11B2 (0.55) | CYP11B2TBXAS1 | |
| SCHEMBL2490828 | 0.68 | CHRM2 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9261340 | 0.68 | CYP11B2 (0.60) | CYP11B2TBXAS1 | |
| SCHEMBL3536508 | 0.67 | CYP11B2 (0.55) | CYP11B2TBXAS1CYP11B1GSK3BCDK8 | |
| Hydrochloric Acid SCHEMBL3537661 | 0.66 | CYP11B2 (0.54) | CYP11B2TBXAS1CYP11B1GSK3BCDK8 | |
| SCHEMBL812221 | 0.63 | PRKCZ (0.40) | CYP11B2CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713991-B2 | Imidazo[[1, 5-A] pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2010-05-11 | — | — | US | claimed |
| US-20070197582-A1 | IMIDAZO[[1, 5-A] PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2007-08-23 | — | — | US | claimed |
| US-7223866-B2 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2007-05-29 | — | — | US | claimed |
| US-20060058342-A1 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2006-03-16 | — | — | US | claimed |
| US-7713991-B2 | Imidazo[[1, 5-A] pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2010-05-11 | — | — | US | disclosed |
| US-7713991-B2 | Imidazo[[1, 5-A] pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2010-05-11 | — | — | US | disclosed |
| US-7713991-B2 | Imidazo[[1, 5-A] pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2010-05-11 | — | — | US | disclosed |
| EP-1565463-B1 | IMIDAZO[1,5A] PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| US-20070197582-A1 | IMIDAZO[[1, 5-A] PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2007-08-23 | — | — | US | disclosed |
| US-20070197582-A1 | IMIDAZO[[1, 5-A] PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2007-08-23 | — | — | US | disclosed |
| US-20070197582-A1 | IMIDAZO[[1, 5-A] PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2007-08-23 | — | — | US | disclosed |
| US-7223866-B2 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2007-05-29 | — | — | US | disclosed |
| US-7223866-B2 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2007-05-29 | — | — | US | disclosed |
| US-7223866-B2 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2007-05-29 | — | — | US | disclosed |
| US-20060058342-A1 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | NOVARTIS AG (CH) | 2006-03-16 | — | — | US | disclosed |
| EP-1565463-A1 | IMIDAZO[1,5A]PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | Novartis AG (CH) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004046145-A1 | IMIDAZO[1, 5A]PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2004-06-03 | — | — | WO | disclosed |
| WO-2004046145-A1 | IMIDAZO[1, 5A]PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | NOVARTIS AG (CH) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058342-A1 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases | CYP11B1, CYP17A1, CYP27A1 | CYP11B2 8/4885CHRM2 1867/4885CHRM4 2491/4885 |
| US-20070197582-A1 | IMIDAZO[[1, 5-A] PYRIDINE DERIVATIVES AND METHODS FOR TREATING ALDOSTERONE MEDIATED DISEASES | CYP11B1, CYP27A1, CYP17A1 | CYP11B2 7/4885CHRM2 1704/4885CHRM4 2306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.