SCHEMBL3536366

SCHEMBL3536366

COc1ccc(-c2nc(COC3CCCCO3)c(CCl)o2)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.43
NPC1 O15118 1/20 0.43
KDM4E B2RXH2 4/20 0.41
ALDH1A1 P00352 4/20 0.41
GAA P10253 3/20 0.41
HPGD P15428 3/20 0.41
HSD17B10 Q99714 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TP53 P04637 1/20 0.41
TARBP2 Q15633 1/20 0.36
KDM4C Q9H3R0 1/20 0.35
MAOB P27338 1/20 0.35
PPARA Q07869 1/20 0.35
APP P05067 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3537723 0.90 TP53 (0.45) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL13770833 0.87 APP (0.34) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL3533285 0.86 RAB9A (0.44) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL3534072 0.83 RAB9A (0.40) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL3768515 0.81 ALDH1A1 (0.43) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL3773297 0.80 ALDH1A1 (0.46) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL3540745 0.79 TARBP2 (0.49) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL3533843 0.77 TARBP2 (0.63) RAB9ANPC1KDM4EALDH1A1GAA
SCHEMBL8321396 0.75 NPC1 (0.50) RAB9ANPC1KDM4EKDM4CMEN1
SCHEMBL23531795 0.70 NPC1 (0.49) RAB9ANPC1HPGDKDM4CAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1934206-B1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2011-12-14 EP disclosed
EP-1934206-B1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2011-12-14 EP disclosed
US-7851493-B2 Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals SANOFI-AVENTIS (FR) 2010-12-14 US disclosed
US-7851493-B2 Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals SANOFI-AVENTIS (FR) 2010-12-14 US disclosed
US-7851493-B2 Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals SANOFI-AVENTIS (FR) 2010-12-14 US disclosed
US-7709509-B2 Oxadiazolones and derivatives thereof as peroxisome proliferator-activated receptor (PPAR) delta agonists SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2010-05-04 US disclosed
US-7709509-B2 Oxadiazolones and derivatives thereof as peroxisome proliferator-activated receptor (PPAR) delta agonists SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2010-05-04 US disclosed
US-7709509-B2 Oxadiazolones and derivatives thereof as peroxisome proliferator-activated receptor (PPAR) delta agonists SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2010-05-04 US disclosed
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (FR) 2009-11-12 US disclosed
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (FR) 2009-11-12 US disclosed
US-20080255212-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-10-16 US disclosed
US-20080255212-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-10-16 US disclosed
EP-1934206-A1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Sanofi-Aventis (FR) 2008-06-25 EP disclosed
US-20070179191-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PPAR DELTA AGONISTS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-08-02 US disclosed
US-20070179191-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PPAR DELTA AGONISTS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-08-02 US disclosed
US-20070179191-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PPAR DELTA AGONISTS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-08-02 US disclosed
WO-2007039172-A1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (DE) 2007-04-12 WO disclosed
WO-2007039172-A1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (DE) 2007-04-12 WO disclosed
EP-1740583-A1 OXADIAZOLONE DERIVATIVES AS PPAR DELTA AGONISTS Sanofi-Aventis Deutschland GmbH (DE) 2007-01-10 EP disclosed
WO-2005097786-A1 OXADIAZOLONE DERIVATIVES AS PPAR DELTA AGONISTS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-10-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070179191-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PPAR DELTA AGONISTS PPARD, PPARA, PPARG RAB9A 4136/4885NPC1 2360/4885KDM4E 4578/4885
US-20080255212-A1 OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS PPARD, PPARG, PPARA RAB9A 3431/4885NPC1 2898/4885KDM4E 3669/4885
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS PPARD, PPARA, PPARG RAB9A 4494/4885NPC1 1114/4885KDM4E 2892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.