Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533653 | 0.92 | HTR2A (0.51) | HTR2ASLC6A2HTR6TAAR1KDM4E | |
| SCHEMBL3532382 | 0.79 | HTR6 (0.38) | HTR2ASLC6A2HTR6ALDH1A1 | |
| SCHEMBL3536576 | 0.79 | SLC6A2 (0.35) | HTR2ASLC6A2HTR6KDM4EALDH1A1 | |
| SCHEMBL3533773 | 0.77 | SLC6A2 (0.49) | HTR2ASLC6A2HTR6ALDH1A1 | |
| SCHEMBL3536066 | 0.77 | SLC6A2 (0.47) | HTR2ASLC6A2HTR6TAAR1HTR1A | |
| SCHEMBL3532415 | 0.76 | HTR2A (0.50) | HTR2ASLC6A2HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL3536330 | 0.76 | SLC6A2 (0.48) | HTR2ASLC6A2HTR6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3538337 | 0.76 | SLC6A2 (0.46) | HTR2ASLC6A2HTR6TAAR1HTR1A | |
| SCHEMBL3535808 | 0.75 | HTR6 (0.48) | HTR2ASLC6A2HTR6KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3530170 | 0.75 | HTR2A (0.49) | HTR2ASLC6A2HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723329-B2 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2010-05-25 | — | — | US | disclosed |
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20070037802-A1 | such as N,N-Dimethyl-3-{[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]oxy}propan-1-amine, used for the treatment of a central nervous system disorders | WYETH (US) | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037802-A1 | such as N,N-Dimethyl-3-{[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]oxy}propan-1-amine, used for the treatment of a central nervous system disorders | HTR6, TPH1, HTR1A | HTR2A 11/4885SLC6A2 47/4885HTR6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.