Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519223 | 0.92 | TRPV4 (0.47) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL29636402 | 0.84 | TRPV4 (0.55) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL2127233 | 0.84 | TRPV4 (0.55) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL15031545 | 0.84 | TTR (0.46) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL28298273 | 0.82 | TRPV4 (0.53) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL3411402 | 0.79 | TSHR (0.49) | SLC6A4SLC6A2ALDH1A1MEN1KMT2A | |
| SCHEMBL19697763 | 0.77 | TRPV4 (0.48) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL624403 | 0.77 | TSHR (0.47) | SLC6A4SLC6A2SLC6A3LMNAALDH1A1 | |
| SCHEMBL4289243 | 0.77 | CYP3A4 (0.45) | TRPV4SLC6A4KCNH2LMNAALDH1A1 | |
| SCHEMBL29273440 | 0.77 | TRPV4 (0.48) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645773-B2 | Thiazoles as inhibitors of 11β-hydroxysteroid dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2010-01-12 | — | — | US | disclosed |