Sugi Predict

Sugi Predict / Compounds / SCHEMBL2127233

SCHEMBL2127233

SCHEMBL2127233

COc1ccc(Cl)cc1OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.55
▸ CA2 P00918 2/20 0.54
▸ ACHE P22303 1/20 0.54
▸ CA12 O43570 1/20 0.54
▸ CA1 P00915 1/20 0.54
▸ CA7 P43166 1/20 0.54
▸ CA9 Q16790 1/20 0.54
▸ CA14 Q9ULX7 1/20 0.54
▸ ALDH1A1 P00352 4/20 0.51
▸ TP53 P04637 1/20 0.51
▸ SLC6A2 P23975 2/20 0.50
▸ SLC6A4 P31645 2/20 0.50
▸ SLC6A3 Q01959 2/20 0.50
▸ TTR P02766 2/20 0.50
▸ HTR3E A5X5Y0 2/20 0.50
▸ HTR3B O95264 2/20 0.50
▸ HTR3A P46098 2/20 0.50
▸ HTR3D Q70Z44 2/20 0.50
▸ HTR3C Q8WXA8 2/20 0.50
▸ KCNH2 Q12809 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29636402 1.00 TRPV4 (0.55) TRPV4CA2ACHECA12CA1
SCHEMBL28298273 0.97 TRPV4 (0.53) TRPV4CA2ACHECA12CA1
Acetic Acid SCHEMBL10997206 0.87 TTR (0.55) TRPV4CA2CA12CA1CA7
SCHEMBL4344793 0.86 TRPV4 (0.48) TRPV4CA2ACHECA12CA1
SCHEMBL29273440 0.86 TRPV4 (0.48) TRPV4CA2ACHECA12CA1
SCHEMBL19697763 0.86 TRPV4 (0.48) TRPV4CA2ACHECA12CA1
SCHEMBL4350642 0.86 TRPV4 (0.48) TRPV4CA2ACHECA12CA1
SCHEMBL3537469 0.84 TRPV4 (0.47) TRPV4CA2ACHECA12CA1
SCHEMBL519223 0.84 TRPV4 (0.47) TRPV4CA2ACHECA12CA1
SCHEMBL19088280 0.83 TRPV4 (0.46) TRPV4ALDH1A1TP53SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106045864-A Production process for preparing 4-chloro-2,5-dimethoxyaniline with hydrazine hydrate catalytic reduction method 洛阳卓特化工有限公司 2016-10-26 — — CN claimed
CN-101510622-B Electrolyte for lithium ion secondary battery and battery containing the electrolyte BYD CO LTD 2012-07-04 — — CN claimed
CN-101510622-A Electrolyte for lithium ion secondary battery and battery containing the electrolyte BYD CO LTD (CN) 2009-08-19 — — CN claimed
EP-1879567-A1 AMINO ACID DERIVATIVES Pfizer Limited (GB) 2008-01-23 — — EP claimed
US-20060247291-A1 Amino acid derivatives PFIZER, INC. 2006-11-02 — — US claimed
WO-2006114707-A1 AMINO ACID DERIVATIVES PFIZER LIMITED (GB) 2006-11-02 — — WO claimed
EP-0295474-B1 CHLOROMETAPHENYLENEDIAMINES, THEIR USE AS COUPLING AGENTS IN OXYDATION COLOURING OF KERATINIC FIBRES, COLOURITY COMPOSITIONS FOR HAIR CONTAINING THESE COMPOUNDS AND COLOURING PROCESS USING THESE COMPOSITIONS L'OREAL (FR) 1991-07-17 — — EP claimed
EP-0211271-B1 PROCESS FOR THE PREPARATION OF VERATRYL CYANIDE BASF Aktiengesellschaft (DE) 1988-10-12 — — EP claimed
US-4661610-A Preparation of veratryl cyanide BASF AKTIENGESELLSCHAFT (DE) 1987-04-28 — — US claimed
CN-118184502-B Method for preparing veratone 济南悟通生物科技有限公司 2024-08-16 — — CN disclosed
CN-118184502-A Method for preparing veratone 济南悟通生物科技有限公司 2024-06-14 — — CN disclosed
US-20220162172-A1 QUINAZOLINONE COMPOUNDS CEREPEUT, INC. 2022-05-26 — — US disclosed
CN-112573978-B High-efficiency halogenation synthesis method of aryl halide 北京大学 2022-05-13 — — CN disclosed
CN-112573978-A High-efficiency halogenation synthesis method of aryl halide 北京大学 2021-03-30 — — CN disclosed
EP-0088849-A1 Levorotatory compounds of N-substituted benzenesulphone amides, process for their preparation and pharmaceutical compositions containing them CHOAY S.A. (FR) 1983-09-21 — — EP disclosed
EP-0081425-A1 Pharmaceutical compositions having normolipemic properties and containing compounds of the n-substituted benzenesulfonamide type CHOAY S.A. (FR) 1983-06-15 — — EP disclosed
EP-0064445-A1 N-substituted 2,4-dialkoxybenzene sulfon amides CHOAY S.A. (FR) 1982-11-10 — — EP disclosed
EP-0064027-A1 Benzodioxole derivatives, process for their preparation and pharmaceutical compositions containing them CIBA-GEIGY AG (CH) 1982-11-03 — — EP disclosed
EP-0064006-A1 Substituted 2,4-dialkoxybenzenesulfonyl chlorides CHOAY S.A. (FR) 1982-11-03 — — EP disclosed
US-4022900-A Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents MARION LABORATORIES, INC. (US) 1977-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220162172-A1 QUINAZOLINONE COMPOUNDS NDUFAB1, NDUFV1, NDUFV2 TRPV4 2807/4885CA2 3439/4885ACHE 2016/4885
US-20060247291-A1 Amino acid derivatives OPRL1, BCAT2, BCAT1 TRPV4 140/4885CA2 507/4885ACHE 155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.