Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3541848 | 0.99 | MAPT (0.40) | CNR1NAMPTMAPTSOAT2SOAT1 | |
| SCHEMBL3540288 | 0.96 | RAB9A (0.39) | NAMPTMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL3543021 | 0.94 | BCHE (0.40) | CNR1NAMPTMAPTMEN1ALDH1A1 | |
| SCHEMBL3540203 | 0.91 | BCHE (0.39) | NAMPTMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL3542109 | 0.82 | GBA1 (0.43) | MAPTMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL3546868 | 0.81 | HTR2C (0.43) | CNR1MAPTMEN1ALDH1A1LMNA | |
| SCHEMBL3551076 | 0.75 | CNR2 (0.41) | CNR1MAPTMEN1KMT2A | |
| SCHEMBL16118213 | 0.69 | LMNA (0.61) | CNR1SOAT2SOAT1ALDH1A1LMNA | |
| SCHEMBL3546148 | 0.68 | ACHE (0.40) | MAPTMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL3867110 | 0.68 | MAPT (0.55) | MAPTALDH1A1LMNAKMT2AENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | claimed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | claimed |
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662831-B2 | Tetracyclic indoles as potassium channel modulators | WYETH LLC (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027090-A1 | TETRACYCLIC INDOLES AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNA5, KCNK5 | CNR1 161/4885NAMPT 2557/4885MAPT 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.