Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 18/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 16/20 | 0.68 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | DMPK | Q09013 | 1/20 | 0.48 |
| ▸ | MYLK | Q15746 | 1/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777330 | 0.91 | ROCK1 (0.66) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL352614 | 0.90 | ROCK1 (0.67) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL353303 | 0.90 | ROCK1 (0.67) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL19119539 | 0.90 | ROCK1 (0.67) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL10237515 | 0.90 | ROCK1 (0.67) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| Hydrochloric Acid SCHEMBL355183 | 0.89 | ROCK1 (0.66) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL353725 | 0.89 | ROCK1 (0.66) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL353543 | 0.88 | ROCK2 (0.62) | ROCK1ROCK2ATG4BEPHX2 | |
| SCHEMBL3651578 | 0.88 | ROCK1 (0.64) | ROCK1ROCK2ATG4BPRKACA | |
| SCHEMBL3651574 | 0.87 | ROCK1 (0.63) | ROCK1ROCK2ATG4BSGK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | disclosed |
| US-8148380-B2 | Antibacterial amide and sulfonamide substituted heterocyclic urea compounds | CRESTONE, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | CRESTONE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | NAAA, AADAC, RPSA | ROCK1 4747/4885ROCK2 4626/4885ATG4B 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.