RPSA

Small ribosomal subunit protein uS2 · P08865 · RPSA on Sugi Atlas →

3,701 patent compounds predicted against RPSA, 1,950 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5500526	0.41	4/20
SCHEMBL5500532	0.41	4/20
SCHEMBL5503310	0.41	4/20
SCHEMBL11844361	0.35	4/20
SCHEMBL2000440	0.39	3/20
SCHEMBL8219903	0.36	3/20
SCHEMBL11627320	0.34	3/20
SCHEMBL10271044	0.55	2/20
SCHEMBL6394396	0.47	2/20
N-Methylpiperidine (SCHEMBL11205373)	0.42	2/20
Bicarbonate (SCHEMBL9058396)	0.42	2/20
SCHEMBL4960293	0.41	2/20
SCHEMBL4961968	0.40	2/20
SCHEMBL6686992	0.40	2/20
SCHEMBL9429122	0.38	2/20
Chloramphenicol (SCHEMBL10796001)	1.00	1/20
Geneticin (SCHEMBL15596)	0.93	1/20
Geneticin (SCHEMBL5006573)	0.93	1/20
Geneticin (SCHEMBL9920496)	0.93	1/20
Chloramphenicol (SCHEMBL16111)	0.90	1/20

Clinical trials — most relevant to RPSA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Sirolimus Treatment for Refractory PRCA	PHASE4	COMPLETED
Tacrolimus Treatment for Refractory PRCA	PHASE4	UNKNOWN
Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA	PHASE4	COMPLETED
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients	PHASE2	COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia	PHASE1	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)	nan	RECRUITING
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
SWE to Detect Enthesitis in PsA: Relationship With SIRT2 Expression and Disease Activity	nan	NOT_YET_RECRUITING
Natural History and Genetic Studies of Usher Syndrome	nan	COMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
miR-155 Expression in Episodic and Chronic Migraine	nan	UNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Trichomonas Vaginalis Genotyping in Upper Egypt	nan	UNKNOWN
Na+ Channel mRNA Regulation in Heart Failure	nan	COMPLETED
Role of RPL8 Protein Alterations in High-grade Serous Ovarian Carcinoma	nan	RECRUITING
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a RPSA binder may also engage these)

Protein	Name	Similarity
G1TLT8	—	1.000	G1TLT8 →
P14206	—	1.000	P14206 →
Q2L9X0	—	1.000	Q2L9X0 →
B5FXT6	—	1.000	B5FXT6 →
P26452	—	1.000	P26452 →
P38982	—	1.000	P38982 →
Q6P8D1	—	1.000	Q6P8D1 →
Q4GWZ2	—	1.000	Q4GWZ2 →
P50890	—	1.000	P50890 →
A0A8I5KQE6	—	1.000	A0A8I5KQE6 →
A6YRY8	—	1.000	A6YRY8 →
P38983	—	1.000	P38983 →
Q4QY71	—	1.000	Q4QY71 →
Q3ZM03	—	1.000	Q3ZM03 →
B5DGB6	—	1.000	B5DGB6 →
P38981	—	1.000	P38981 →
C0NKW7	—	1.000	C0NKW7 →
B2B1Z3	—	1.000	B2B1Z3 →
Q5UAP4	—	1.000	Q5UAP4 →
Q2GV75	—	1.000	Q2GV75 →
A7RKS5	—	1.000	A7RKS5 →
Q803F6	—	1.000	Q803F6 →
Q90YS4	—	1.000	Q90YS4 →
A6NA00	—	1.000	A6NA00 →
Q8H173	—	1.000	Q8H173 →
B6K1S2	—	1.000	B6K1S2 →
C5PA09	—	1.000	C5PA09 →
Q4WYK1	—	1.000	Q4WYK1 →
Q5B8F8	—	1.000	Q5B8F8 →
Q0PXX8	—	1.000	Q0PXX8 →