Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | PRKX | P51817 | 2/20 | 0.44 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.44 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405650 | 0.80 | MAOB (0.66) | ROCK2ROCK1CLK4GSK3AGSK3B | |
| SCHEMBL2802570 | 0.77 | ROCK2 (0.82) | ROCK2ROCK1 | |
| SCHEMBL2802571 | 0.77 | ROCK2 (0.82) | ROCK2ROCK1 | |
| SCHEMBL13122214 | 0.74 | INSR (0.54) | KDRROCK2INSRIGF1RTRPM5 | |
| SCHEMBL13122085 | 0.74 | CDC7 (0.56) | KDRROCK2INSRIGF1RTRPM5 | |
| SCHEMBL13122080 | 0.74 | ROCK2 (0.67) | ROCK2INSRIGF1RTRPM5ROCK1 | |
| SCHEMBL13122150 | 0.74 | ROCK2 (0.57) | ROCK2INSRIGF1RTRPM5ROCK1 | |
| SCHEMBL13122152 | 0.74 | TRPM5 (0.60) | KDRROCK2INSRIGF1RTRPM5 | |
| SCHEMBL5334521 | 0.72 | SYK (0.46) | KDRROCK2ROCK1DYRK1ASYK | |
| SCHEMBL17741867 | 0.72 | PDE2A (0.48) | GSK3BRPS6KB1DYRK1AAURKAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | KDR 2852/4885ROCK2 200/4885INSR 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.