Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544436 | 1.00 | NR1H4 (0.42) | NR1H4KDM4EALDH1A1HPGDFFAR4 | |
| SCHEMBL13030974 | 0.81 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDFFAR4LMNA | |
| SCHEMBL138676 | 0.79 | NR1H4 (0.49) | NR1H4ALDH1A1LMNAKMT2A | |
| SCHEMBL138677 | 0.79 | NR1H4 (0.49) | NR1H4ALDH1A1LMNAKMT2A | |
| SCHEMBL26080824 | 0.72 | MEN1 (0.53) | NR1H4ALDH1A1LMNACYP2C9KMT2A | |
| SCHEMBL3543365 | 0.72 | FFAR4 (0.42) | FFAR4RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL143636 | 0.70 | NR1H4 (0.50) | NR1H4ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL143637 | 0.70 | NR1H4 (0.50) | NR1H4ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL13030975 | 0.68 | KLK5 (0.53) | ALDH1A1LMNAKMT2A | |
| SCHEMBL13241270 | 0.68 | MEN1 (0.58) | NR1H4ALDH1A1LMNACYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834007-B2 | CGRP antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-11-16 | — | — | US | disclosed |
| US-20070049577-A1 | CGRP antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049577-A1 | CGRP antagonists | CALCRL, CALCR, CALCA | NR1H4 694/4885KDM4E 4678/4885ALDH1A1 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.