Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6738802 | 0.92 | SLC18A3 (0.42) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| SCHEMBL2346417 | 0.84 | TAAR1 (0.42) | SLC6A2SLC6A4HRH1CYP2D6MEN1 | |
| SCHEMBL3837450 | 0.83 | SLC6A2 (0.62) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| Hydrochloric Acid SCHEMBL18263847 | 0.81 | SLC6A2 (0.60) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| SCHEMBL28581310 | 0.79 | KDM4E (0.46) | MEN1LMNAKMT2A | |
| SCHEMBL4010135 | 0.79 | SLC18A3 (0.45) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| SCHEMBL28054166 | 0.79 | SLC18A3 (0.45) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| SCHEMBL22634123 | 0.79 | SLC18A3 (0.45) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| Hydrochloric Acid SCHEMBL4389599 | 0.78 | SLC6A2 (0.44) | SLC18A3SIGMAR1SLC6A2SLC6A4HRH1 | |
| SCHEMBL620016 | 0.77 | KDM4E (0.49) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705042-B2 | Class of arylamide compounds useful as inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-27 | — | — | US | disclosed |
| EP-1807407-B1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-29 | — | — | EP | disclosed |
| EP-1807407-A1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | disclosed |
| US-20060100201-A1 | Inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | US | disclosed |
| WO-2006047504-A1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100201-A1 | Inhibitors of c-fms kinase | MUSK, FLT3, FES | SLC18A3 4808/4885SIGMAR1 1717/4885SLC6A2 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.