Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.34 |
| ▸ | AURKA | O14965 | 5/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544753 | 0.81 | TMEM97 (0.46) | SLC6A5HDAC4HDAC6ALDH1A1TMEM97 | |
| SCHEMBL6753601 | 0.78 | SCN9A (0.38) | PTGER1RPS6KB1AURKAAURKBKDM4E | |
| SCHEMBL3541193 | 0.77 | LSS (0.45) | SMN1; SMN2TMEM97SIGMAR1KMT2A | |
| SCHEMBL6753593 | 0.72 | CCR2 (0.40) | RPS6KB1AURKAAURKBKDM4EALDH1A1 | |
| SCHEMBL4425790 | 0.68 | KDM4E (0.53) | SLC6A5RPS6KB1AURKAAURKBKDM4E | |
| SCHEMBL3545170 | 0.66 | POLB (0.41) | KDM4EALDH1A1SMN1; SMN2SIGMAR1KMT2A | |
| SCHEMBL3351112 | 0.62 | KDM6B (0.46) | SLC6A5HDAC6SCN8ATMEM97SIGMAR1 | |
| SCHEMBL4423057 | 0.61 | SCN8A (0.51) | ALDH1A1SCN8ATMEM97SIGMAR1SCN9A | |
| SCHEMBL23377632 | 0.61 | SCN8A (0.53) | ALDH1A1SMN1; SMN2SCN8A | |
| SCHEMBL6009391 | 0.60 | SCN8A (0.49) | SLC6A5HDAC4HDAC6SCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683078-B2 | Arylsulfonamide derivatives as C-Jun-N-Terminal Kinases (JNK's) inhibitors | LABORATOIRES SERONO S.A. (CH) | 2010-03-23 | — | — | US | claimed |