Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545167 | 0.82 | ALDH1A1 (0.50) | POLBALDH1A1MEN1KMT2ADRD4 | |
| SCHEMBL3547611 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6753593 | 0.75 | CCR2 (0.40) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6753601 | 0.73 | SCN9A (0.38) | ALDH1A1PARP1PARP2KDM4ESMN1; SMN2 | |
| SCHEMBL3545198 | 0.66 | CCR2 (0.54) | KMT2ANPC1 | |
| SCHEMBL3544748 | 0.66 | SLC6A5 (0.37) | ALDH1A1KMT2ASIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL3782330 | 0.65 | ALDH1A1 (0.59) | POLBALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL13059810 | 0.65 | ALDH1A1 (0.59) | POLBALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL8328663 | 0.65 | CYP2D6 (0.65) | POLBALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL4425790 | 0.65 | KDM4E (0.53) | ALDH1A1PARP1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683078-B2 | Arylsulfonamide derivatives as C-Jun-N-Terminal Kinases (JNK's) inhibitors | LABORATOIRES SERONO S.A. (CH) | 2010-03-23 | — | — | US | claimed |