SCHEMBL354509

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL450066	0.84	TSHR (0.39)	TSHRTHRBLMNAALDH1A1CYP3A4
	SCHEMBL355615	0.83	THRB (0.41)	TSHRTHRBCYP2D6LMNACYP1A2
	SCHEMBL453097	0.82	TSHR (0.40)	TSHRTHRBLMNAALDH1A1CYP3A4
	SCHEMBL355275	0.82	TSHR (0.40)	TSHRTHRBLMNAALDH1A1CYP3A4
	SCHEMBL11121424	0.82	TSHR (0.50)	TSHRTHRBLMNAALDH1A1CYP3A4
	SCHEMBL11121418	0.82	TSHR (0.50)	TSHRTHRBLMNAALDH1A1CYP3A4
	SCHEMBL10697522	0.80	THRB (0.55)	TSHRTHRBCYP2D6LMNACYP1A2
	SCHEMBL28655092	0.79	TSHR (0.59)	TSHRTHRBCYP2D6LMNACYP1A2
	SCHEMBL354333	0.77	THRB (0.54)	TSHRTHRBALDH1A1CYP3A4POLB
	SCHEMBL28273630	0.77	THRB (0.55)	TSHRTHRBCYP2D6LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.