Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.57 |
| ▸ | GRM5 | P41594 | 11/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30270466 | 0.93 | PDK4 (0.63) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL3466789 | 0.88 | PDK4 (0.58) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL2877448 | 0.87 | PDK4 (0.57) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL4542408 | 0.86 | GRM1 (0.56) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL17223048 | 0.86 | PDK4 (0.56) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL29915662 | 0.86 | PDK4 (0.56) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL23216670 | 0.86 | PDK4 (0.58) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL29768388 | 0.86 | PDK4 (0.58) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL12883597 | 0.86 | PDK4 (0.53) | PDK4GRM1GRM5NAMPTHTR6 | |
| SCHEMBL18739607 | 0.84 | PDK4 (0.54) | PDK4GRM1GRM5NAMPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732463-B2 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2010-06-08 | — | — | US | disclosed |
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | H.LUNDBECK A/S (DK) | 2006-05-11 | — | — | US | disclosed |
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100242-A1 | such as 4-[2-(4-Chloro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-piperidine, used as antidepressants and anxiolytic agents; treatment of panic and obsessive compulsive disorders | HTR4, HTR5A, TPH1 | PDK4 99/4885GRM1 137/4885GRM5 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.