⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6104479 | 0.93 | LMNA (0.52) | — | |
| SCHEMBL2722289 | 0.91 | TSHR (0.55) | — | |
| SCHEMBL7261781 | 0.91 | TSHR (0.55) | — | |
| SCHEMBL384401 | 0.87 | — | — | |
| SCHEMBL225702 | 0.84 | TSHR (0.71) | — | |
| SCHEMBL94565 | 0.84 | TSHR (0.71) | — | |
| SCHEMBL23046863 | 0.81 | TSHR (0.77) | — | |
| SCHEMBL18313750 | 0.80 | — | — | |
| SCHEMBL154914 | 0.79 | — | — | |
| SCHEMBL4459033 | 0.79 | TSHR (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834406-B2 | Conjugates of cell binding molecules with cytotoxic agents | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-12-05 | — | — | US | disclosed |
| US-11767294-B2 | Conjugates of cell binding molecules with cytotoxic agents | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-09-26 | — | — | US | disclosed |
| US-20190330149-A1 | CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2019-10-31 | — | — | US | disclosed |
| US-7781488-B2 | convergent assembly of a plurality of pairs of oligopeptides; stable C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester; allows a single precursor to participate in a succession of chemical ligation reactions | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7667054-B2 | chemically linking the taxane to a cell binding agent such as monoclonal antibody for tumor antigen; taxane has extra ether bridge group, and chemical group for conjugation such as mercapto | AVENTIS PHARMA S.A. (FR) | 2010-02-23 | — | — | US | disclosed |
| US-7598290-B2 | Cytotoxic agents comprising new C-2 modified taxanes | IMMUNOGEN, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070270482-A1 | Cytotoxic Agents Comprising New C-2 Modified Taxanes | AVENTIS PHARMA S.A. (FR) | 2007-11-22 | — | — | US | disclosed |
| EP-1824858-A2 | CYTOTOXIC AGENTS COMPRISING NEW TAXANES | Aventis Pharma S.A. (FR) | 2007-08-29 | — | — | EP | disclosed |
| EP-1819687-A2 | CYTOTOXIC AGENTS COMPRISING NEW C-2 MODIFIED TAXANES | Aventis Pharma S.A. (FR) | 2007-08-22 | — | — | EP | disclosed |
| US-20070059792-A1 | convergent assembly of a plurality of pairs of oligopeptides; stable C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester; allows a single precursor to participate in a succession of chemical ligation reactions | ASTRAZENECA PHARMACEUTICALS LP | 2007-03-15 | — | — | US | disclosed |
| EP-1313738-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | Immunogen, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1259482-A2 | SULFUR CONTAINING COMPOUNDS | University Health Network (CA) | 2002-11-27 | — | — | EP | disclosed |
| WO-2002016368-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | IMMUNOGEN, INC. (US) | 2002-02-28 | — | — | WO | disclosed |
| US-6333410-B1 | REDUCTIVE HYDROLYSIS OF C3 ESTER WITH LITHIUM TRIMETHOXYALUMINUM HYDRIDE TO YIELD THE MANTANSINOL; ESTERIFYING THE A DISULFIDE-CONTAINING CARBOXYLIC ACID; REDUCING TO YIELD A THIOL-CONTAINING MAYTANSINOID | IMMUNOGEN, INC. | 2001-12-25 | — | — | US | disclosed |
| WO-2001062668-A2 | SULFUR CONTAINING COMPOUNDS | UNIVERSITY HEALTH NETWORK (CA) | 2001-08-30 | — | — | WO | disclosed |
| EP-0425235-B1 | Cytotoxic agents comprising maytansinoids and their therapeutic use | IMMUNOGEN INC (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5416064-A | Antitumor agents | IMMUNOGEN, INC. (US) | 1995-05-16 | — | — | US | disclosed |
| US-5208020-A | Cytotoxic agents comprising maytansinoids and their therapeutic use | IMMUNOGEN INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0425235-A2 | Cytotoxic agents comprising maytansinoids and their therapeutic use | IMMUNOGEN INC (US) | 1991-05-02 | — | — | EP | disclosed |
| EP-0232075-B1 | INSECTICIDAL N'-SUBSTITUTED-N-ALKYLCARBONYL-N'-ACYL HYDRAZINES | ROHM AND HAAS COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |