Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR3A | P46098 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | NCF1 | P14598 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532010 | 0.93 | KEAP1 (0.64) | KEAP1ADRB1ADRA2CHTR6HTR7 | |
| Hydrochloric Acid SCHEMBL4684126 | 0.91 | KEAP1 (0.62) | KEAP1ADRB1ADRA2CHTR6HTR7 | |
| SCHEMBL29938274 | 0.82 | KEAP1 (0.95) | KEAP1ADRA2CNCF1HSD17B10MEN1 | |
| SCHEMBL30664040 | 0.82 | KEAP1 (0.87) | KEAP1ADRA2CNCF1HSD17B10MEN1 | |
| SCHEMBL484010 | 0.82 | KEAP1 (0.95) | KEAP1ADRA2CNCF1HSD17B10MEN1 | |
| SCHEMBL27597451 | 0.81 | KEAP1 (0.55) | KEAP1ADRB1ADRA2CHTR6HTR7 | |
| SCHEMBL17738698 | 0.81 | KEAP1 (0.44) | KEAP1ADRB1HTR6HTR7HTR1A | |
| SCHEMBL73609 | 0.81 | KEAP1 (1.00) | KEAP1ADRA2CNCF1HSD17B10MEN1 | |
| SCHEMBL17276365 | 0.81 | ADRB1 (0.67) | ADRB1HTR6HTR7HTR1AHTR3A | |
| SCHEMBL22652955 | 0.81 | ADRB1 (0.67) | ADRB1HTR6HTR7HTR1AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | KEAP1 1485/4885ADRB1 37/4885ADRA2C 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.