Sugi Predict

Sugi Predict / Compounds / SCHEMBL73609

SCHEMBL73609

SCHEMBL73609

Nc1ccccc1N1CCCCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 1.00
▸ ADRA2C P18825 1/20 0.64
▸ GAA P10253 7/20 0.60
▸ MEN1 O00255 2/20 0.60
▸ KMT2A Q03164 2/20 0.60
▸ USP2 O75604 1/20 0.60
▸ ALDH1A1 P00352 4/20 0.57
▸ HTT P42858 3/20 0.57
▸ S100B P04271 2/20 0.57
▸ MAPK1 P28482 2/20 0.57
▸ LMNA P02545 2/20 0.57
▸ TDP1 Q9NUW8 2/20 0.57
▸ L3MBTL1 Q9Y468 2/20 0.57
▸ MAPT P10636 1/20 0.57
▸ PKM P14618 1/20 0.57
▸ ALOX15 P16050 1/20 0.57
▸ KDM4E B2RXH2 4/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ POLB P06746 2/20 0.49
▸ HSD17B10 Q99714 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3083172 1.00 KEAP1 (1.00) KEAP1ADRA2CGAAMEN1KMT2A
SCHEMBL29947204 1.00 KEAP1 (1.00) KEAP1ADRA2CGAAMEN1KMT2A
Hydrochloric Acid SCHEMBL23850930 0.98 KEAP1 (0.96) KEAP1ADRA2CGAAMEN1KMT2A
Hydrochloric Acid SCHEMBL30501407 0.98 KEAP1 (0.96) KEAP1ADRA2CGAAMEN1KMT2A
SCHEMBL29938274 0.98 KEAP1 (0.95) KEAP1ADRA2CGAAMEN1KMT2A
SCHEMBL484010 0.98 KEAP1 (0.95) KEAP1ADRA2CGAAMEN1KMT2A
SCHEMBL30664040 0.93 KEAP1 (0.87) KEAP1ADRA2CGAAMEN1KMT2A
Sulfuric Acid SCHEMBL8339039 0.89 KEAP1 (0.79) KEAP1ADRA2CGAAMEN1KMT2A
SCHEMBL11775877 0.88 ADRA2C (0.79) KEAP1ADRA2CGAAMEN1KMT2A
SCHEMBL23152040 0.88 ADRA2C (0.79) KEAP1ADRA2CGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 415 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7790724-B2 c-fms kinase inhibitors JANSSEN PHARMACEUTICA N.V. (BE) 2010-09-07 — — US claimed
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 — — EP claimed
US-7429603-B2 Such as 5-nitro-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide; diabetes, angiogenesis, psoriasis, restenosis, schizophrenia, rheumatoid arthritis, cardiovascular disease, cancer 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2008-09-30 — — US claimed
US-7427683-B2 c-fms kinase inhibitors ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2008-09-23 — — US claimed
EP-1812425-A2 C-FMS KINASE INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-08-01 — — EP claimed
US-20060258666-A1 c-fms kinase inhibitors JANSSEN PHARMACEUTICA N.V. (BE) 2006-11-16 — — US claimed
WO-2006047479-A2 C-FMS KINASE INHIBITORS JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-04 — — WO claimed
EP-1631560-A2 C-FMS KINASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2006-03-08 — — EP claimed
US-20050131022-A1 C-fms kinase inhibitors JANSSEN PHARMACEUTICA, N.V. (BE) 2005-06-16 — — US claimed
US-20050004112-A1 C-fms kinase inhibitors 3-DIMENSIONAL PHARMACEUTICALS, INC. 2005-01-06 — — US claimed
EP-0428441-A2 Keratinic fibre dyeing compostions containing oxydation dye precursors and derivatives of 4-hydroxyindole as couplers, and dyeing process using same L'OREAL (FR) 1991-05-22 — — EP claimed
EP-0428442-A1 Composition comprising derivatives of 6- or 7-hydroxyindole as couplers and dyeing processes using same L'OREAL (FR) 1991-05-22 — — EP claimed
EP-0424261-A1 Dyeing composition containing oxidation dyes precursors and aminoindole derivatives as coupling agent L'OREAL (FR) 1991-04-24 — — EP claimed
US-4891045-A DYEING HAIR L'OREAL (FR) 1990-01-02 — — US claimed
US-4865617-A Dyeing compositions for keratinous fibres, especially for human hair, containing oxidation dye precursors and heterocyclic couplers L'OREAL (FR) 1989-09-12 — — US claimed
EP-0295474-A1 Chlorometaphenylenediamines, their use as coupling agents in oxydation colouring of keratinic fibres, colourity compositions for hair containing these compounds and colouring process using these compositions L'OREAL (FR) 1988-12-21 — — EP claimed
EP-0294669-A1 Metaphenylendiamines, process for their preparation, intermediate compounds and use of these metaphenylendiamines as couplers in oxydative colouring of keratinic fibres especially of human hair L'OREAL (FR) 1988-12-14 — — EP claimed
US-4200432-A HAIR DYES L'OREAL (FR) 1980-04-29 — — US claimed
US-3961879-A P-PHENYLENEDIAMINE, HAIR L'OREAL (FR) 1976-06-08 — — US claimed
US-3948596-A Oxidation dye for keratinic fibers containing 2-halo-5-acetaminophenol as a coupler SOCIETE ANONYME DITE: L'OREAL (FR) 1976-04-06 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050131022-A1 C-fms kinase inhibitors FLT3, FES, FGR KEAP1 3004/4885ADRA2C 2985/4885GAA 4542/4885
US-20060258666-A1 c-fms kinase inhibitors FLT3, FES, FER KEAP1 2972/4885ADRA2C 2871/4885GAA 4492/4885
US-20050004112-A1 C-fms kinase inhibitors FLT3, FGR, FER KEAP1 3351/4885ADRA2C 2719/4885GAA 4304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.