Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA7 | P43166 | 4/20 | 0.56 |
| ▸ | CA9 | Q16790 | 4/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28510586 | 0.83 | ALDH1A1 (0.51) | GAAHSD17B3SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL29501115 | 0.81 | CA12 (0.71) | CA12CA1CA2CA7CA9 | |
| SCHEMBL162631 | 0.81 | CA12 (0.71) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10564137 | 0.80 | CA12 (0.69) | CA12CA1CA2CA7CA9 | |
| SCHEMBL4209898 | 0.79 | CA12 (0.68) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5132183 | 0.79 | HPGD (0.53) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1483249 | 0.78 | CA12 (0.65) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5082071 | 0.78 | SMN1; SMN2 (0.65) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3356728 | 0.78 | CA12 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL941119 | 0.78 | HSD17B3 (0.62) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816542-B2 | Compounds and compositions as TPO mimetics | IRM LLC (BM) | 2010-10-19 | — | — | US | disclosed |
| US-7816542-B2 | Compounds and compositions as TPO mimetics | IRM LLC (BM) | 2010-10-19 | — | — | US | disclosed |
| US-7816542-B2 | Compounds and compositions as TPO mimetics | IRM LLC (BM) | 2010-10-19 | — | — | US | disclosed |
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | IRM LLC (BM) | 2008-08-14 | — | — | US | disclosed |
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | IRM LLC (BM) | 2008-08-14 | — | — | US | disclosed |
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | IRM LLC (BM) | 2008-08-14 | — | — | US | disclosed |
| EP-1915341-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007022269-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007022269-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | MPL, TPO, THPO | CA12 4600/4885CA1 4857/4885CA2 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.